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Clinical efficacy studies demonstrate that both forms produce meaningful weight loss when used consistently, though individual response varies based on genetics, lifestyle, and adherence

GLP-1 receptor agonists: Targeting both hyperglycaemia and disease processes in diabetes

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The main differences between the two peptides are the following: Development and Approval: Semaglutide was developed later (2010) than liraglutide, and it also received FDA approval much more recently for type 2 diabetes treatment (2017), cardiovascular risk reduction in diabetes (2021) and overweight and obesity management in adults (2021) and adolescents (2023)

Beyond glucose control, semaglutide reduces hepatic fat contentfatty liver is both a cause and consequence of severe insulin resistance

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