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Long-term clinical study results demonstrated that pramlintide reduces HbA1c and body weight without increasing the frequency of severe hypoglycemia when insulin doses are appropriately co-adjusted, addressing a critical safety concern with insulin intensification strategies
Data from these trials shows that this peptide has a positive safety profile and does not produce a high rate of adverse events (AEs) [1]
A small retrospective analysis from 2024 suggested modest additional weight loss (13% more) when topiramate was added to semaglutide in patients who had plateaued, but the effect was inconsistent and accompanied by higher adverse-event rates in 40% of participants
Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial
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