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The progressive degeneration of cholinergic neurons in the brain, particularly in the hippocampus, results in reduced acetylcholine levels, contributing to the cognitive impairments associated with AD

That's called methyl trapping

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These data re-enforce preclinical studies that suggest the antioxidant and anti-inflammatory activities of ergothioneine interfere with atherogenesis and protect vascular and microvascular endothelial cells from oxidative stress and hyperglycaemia (81)

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Replenishing glutathione helps counteract these underlying changes, giving patients a clearer, more energized, and healthier baseline to work from