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There are several underlying reasons for the methyl trap: the concentration of Hcy drops, oxidative stress inhibits MS, and the drop in [SAM] releases the inhibition of MTHFR, which drives more folate towards the 5mTHF form

In the clinical trials that supported Wegovy's approval, taste disturbances were not prominently reported as a significant adverse event

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Rebecca Tobi, the senior business and investor manager at the Food Foundation, a UK charity, says: These drugs will be hugely useful for some people, but we need to see them as treatment and not prevention