Its also advisable not to consume alcohol excessively, as it may increase the risk of pancreatitis
Always consult with a qualified healthcare provider before starting any weight loss medication or treatment program
GIP treatment has been shown to reduce glucolipotoxicity-induced cell death in C57 BL/6 and Bax -/- pancreatic islets, but not GIPR -/- pancreatic islets of the mouse models (114)
But in March 2024, the US Food and Drug Administration expanded the indication of the peptide to help obese people lose weight and reduce the risk of cardiovascular incidents
Clinical trials indicate that Retatrutide side effects are mainly gastrointestinal, with nausea and vomiting, similar to existing GLP-1 treatments
Combination or staged GLP-1 with nutrition therapy Given the existing adherence and cost challenges of GLP-1s coupled with significant weight regain after discontinuation, combination or staged therapy with intensive lifestyle management could promote greater efficacy, cost-effectiveness, and equitable obesity care [3,18,222,[271], [272], [273]]
