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Suppressor of cytokine signaling 1 (SOCS1) is essential for the activation of p53-mediated ferroptosis and regulation of cellular senescence (Calabrese et al., 2009

This process is governed by cAMP and MAPK pathways

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Somehow, the return to a functional balance between oxidant and antioxidant species favors the inhibition of pathways such as MAPK, JNK, and p38MAPK

Last modified Jan-Feb 2006