Individualized treatment: Choose between Rybelsus and Ozempic based on your individual needs, medical history, and treatment goals
Be prepared to have specifics on: Medication details: Exact brand name, dose, protocol, and date/time of most recent dose
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Loomba R, Friedman SL, Shulman GI
Other Key Findings Metabolic improvements: Participants saw reductions in A1C (for those with prediabetes or diabetes), fasting glucose, and triglycerides Liver fat reduction: Retatrutide reduced liver fat by up to 50%, which is why Eli Lilly added a NASH-specific trial to the Phase 3 program Side effects: Mostly gastrointestinal (nausea, diarrhea, constipation), similar to other GLP-1 drugs but manageable with slow titration Discontinuation rate: About 10% of participants stopped due to side effects, comparable to tirzepatide and semaglutide Study limitation: The Phase 2 trial was only 48 weeks long
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