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In addition to GLP-1R and GIPR, these agonists also act as Glucagon Receptor (GCGR) agonists

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It has been used cosmetically to help lighten skin, although it has not been approved by the U.S

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Valizadeh M, Ahmadzadeh A, Behzadi M, Yeganeh F

Retatrutide also reduced pain in patients with knee osteoarthritis, with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain scores dropping by as much as 4.5 points, a 75.8% reduction with the 9 mg dose, compared with a 2.4 point (40.3%) reduction for placebo