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Die in der Literatur am konsistentesten beschriebenen nachgeschalteten Effekte umfassen die Induktion von Kollagen I und III, Elastin und Decorin (Maquart et al., FEBS Letters , 1988), eine Hochregulation der Transkripte von VEGF und bFGF, die Expressionserhhung antioxidativer Enzyme wie SOD2 und diverser Metallothionein-Isoformen sowie eine Verschiebung des MMP-2- und TIMP-1/2-Gleichgewichts in Richtung eines nicht-fibrotischen Umbaus