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This agitation can damage the delicate peptide structure

L., Fields, J

Tirzepatide was developed by Eli Lilly and received FDA approval in May 2022 under the name Mounjaro as a Type 2 diabetes treatment

Furthermore, GLP-1 RAs exhibit vasodilatory effects by promoting endothelial nitric oxide (NO) synthesis, enhancing endothelial function with a consequent reduction of vascular resistance and an improvement in cardiac afterload [45, 46]

Overall, the onset of GI AEs is slightly higher in those trials designed to assess the efficacy and safety of GLP-1 RAs in people with obesity, which may be ascribed to the fact that doses are higher than those used in clinical trials in people with T2D

Example Catalent: The Catalent case illustrates the value of CDMO capacity