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The reduced levels of these enzymes leads to higher levels of the oxidized states of glutathione (written GSSG) and the thioredoxins reducing their roles in detoxification of reactive oxygen species (ROS) with the outcome being increased cellular oxidative damage

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L-Arginine, an amino acid integral in the synthesis of nitric oxide, is recognized for its role in vasodilation, which may enhance blood flow to tissues when applied topically

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