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Severe or persistent dermal reactions represent a smaller subset and typically warrant dose adjustment or temporary treatment interruption

Research published in 2024 analyzing SURMOUNT trial data found consistent and significant differences between men and women on tirzepatide

Loss of elastin contributes to sagging, laxity, and a less youthful appearance

Reduces pigmentation and dark spots with continued use

and the Pharmacy Compounding Advisory Committee subsequently voted against adding it to the Category 1/503A bulk drug substances list at its late-2024 meetings, leaving it without a confirmed legal compounding pathway at that time

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