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The recent evidence shows that the dUTPase protein encoded by EBV and HSV-1 can be transported to the brain via exosomes, where it induces pro-inflammatory cytokine release (e.g., IL-1, IL-6, TNF-) from endothelial cells, astrocytes, and pericytes, thereby degrading tight junction proteins, disrupting BBB integrity and inducing neuroinflammation [80]

NAD+ / MOTS-C / 5-Amino-1MQ appears in research contexts involving NNMT pathway research, NAD metabolism models, metabolic signaling studies

September 18, 2023