Semaglutide works by increasing insulin secretion, decreasing glucagon secretion, slowing gastric emptying, and promoting a feeling of fullness (satiety)
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In SUSTAIN-6, only two observation periods were used: the in-trial observation period, and on-treatment observation period (a subset of the in-trial observation period, which represents the time period where patients were considered exposed to study medication)
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In fact, it may improve insulin sensitivity