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Considering its effects on gut microbiota, the study conducted by Cusotto et al

SahooDKHeilmannRMPaitalBPatelAYadavVKWongDet al

[16] [17] There is limited research suggesting whether GLP-1 receptor agonists might have direct effects on reproductive tissues

While itching is uncommon during semaglutide, genetic factors related to GLP1R expression, inflammatory response, and skin barrier function may influence your personal risk, and this information can help provide context for your provider conversation