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[DOI] [PubMed] [Google Scholar] 59.Papastefanou V.P., Bozas E., Mykoniatis M.G., Grypioti A., Garyfallidis S., Bartsocas C.S., Nicolopoulou-Stamati P

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Low-LET ionizing radiation, for instance, inhibits proteasomal activity and induces free-radical damage to UPS-associated molecules, increasing the risk of tumorigenesis

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This process can be initiated by iron-catalyzed Fenton chemistry, in which hydroxyl radicals (OH) generated from H 2 O 2 trigger a self-propagating lipid peroxidation chain reaction