The benefit of GLP-1 RAs exceeded the harms for weight loss in the first 2 years of treatment, yet the net benefit was dependent on individual treatment goals (10% or 5% weight loss) and willingness to accept harms in pursuit of weight loss
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For the study, which was published last month in the journal Diabetes, Obesity, and Metabolism , researchers at Johns Hopkins University reviewed the medical records of more than 200,000 people with type 1 diabetes from 2008 to 2023
Because these findings are based on limited, recently published datasets with conflicting results, ongoing pharmacovigilance and large-scale prospective studies are needed
Research published in Pharmacy and Therapeutics suggests patients with obesity can lose at least 5 percent of their body weight after using Contrave for 12 weeksand as much as 11.5 percent after 56 weeks
Enteroendocrine L cells sense LPS after gut barrier injury to enhance GLP-1 secretion