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A structure-guided amino acid alignment was performed in PROMALS3D (Pei and Grishin, 2007) using the default parameters with structures of TyrA enzymes from plants and microbes with varying substrate specificities ( G

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(4) The relatively complex structure of linkers leads to difficulties in preclinical studies and in clinical applications

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As with other GLP-1 agonists, retatrutide is likely to be unsuitable for those with a family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome type 2