Many cannabinoids accumulate in fat, and for chronic users, they can take weeks or months to clear completely from the body
Table 2 Examples of microbiota modulation after inulin ingestion
Side Effects & Safety Nausea most common (~33% at high doses), dose-dependent, typically improves over time GI effects vomiting, diarrhea, constipation, slowed gastric emptying (GLP-1 class effects) Heart rate changes transient increases observed in trials, peaked at 24 weeks then declined Injection site reactions mild redness or irritation Gallbladder risk rapid weight loss increases gallstone risk (common with any rapid weight loss method) No major safety signals in 48-week trial up to 12 mg weekly At community doses (1.5 mg/week), side effects are notably milder than high-dose trial groups Dosage Chart This dosage chart consolidates the doses reported in published Phase 2 trials and self-reported community protocols, expressed in milligrams (mg) and converted to units on a standard 100-unit / 1mL insulin syringe
Others prefer to wait until breastfeeding concludes or switch patients to semaglutide, which has slightly more human lactation data
Light brief agitation (a second or two of inadvertent shaking) is unlikely to cause significant degradation
Many patients describe this as feeling like the training wheels are coming off