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For Steglatro (ertugliflozin) a less strong increase could be noted, while for Invokana (canagliflozin) a decreasing trend was observed (Figure 1C)
It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption (see Drug/Laboratory Test Interactions), use of a gluten free diet in nontropical sprue, or administration of antibiotics in tropical sprue
Meanwhile, the incretin hormone glucagon-like peptide 1 (GLP1) mainly facilitates glucose homeostasis and insulin signaling
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Still, both treatments affect the body significantly and should only be combined with medical supervision