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In the cGMP-dependent pathway, NO activates guanylyl cyclase, raising cGMP levels and triggering cyclic-nucleotide-gated channels (CNGCs) that modulate Ca 2+ fluxes

MOTS-c specifically targets skeletal muscle, influencing glucose metabolism and muscle uptake of glucose by increasing the expression of glucose transporters through AMPK activation

ThevaranjanNPuchtaASchulzCNaidooASzamosiJCVerschoorCPet al

Third, while the 1 H-MRS sequence used to measure GABA + and GSH in the present study was a relative strength (i.e., compared to more commonly used 1 H-MRS sequences, which are unable to reliably distinguish GSH or GABA + from overlapping signals at 3 T) (Chan et al

4F), respectively, while these same lipids are unaffected in controls

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