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Just as there have been advances in treating the symptoms of metabolic disease such as weight gain, clinical understanding of the biology and behavior behind metabolic health is improving

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Ethics declarations Ethics approval and consent to participate Human samples for total PBMCs were obtained within the study (Protocol N 10 2 10/2011) approved by the institutional review board ethics committee of IRCCS

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Gastrointestinal side effects, primarily mild nausea and vomiting, were dose-dependent (up to 65% and 60% in the 1.2 mg group vs