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1.4 Historical Development and Regulatory Approval Semaglutide emerged from extensive peptide engineering aimed at prolonging GLP-1 activity

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The injection is small and goes into the fat layer of the abdomen or thigh, similar to other peptide and GLP-1 therapies

Changes in the number of antihypertensive medications required for the management of hypertension at week 68 from baseline did not significantly differ between groups ( P = 0.087)

2 Administration: Taken nightly, five days per week, on an empty stomach for optimal potential outcomes