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doi: 10.1016/S0953-6205(02)00183-8

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612 NMN treatment improves the neuronal functions, including rescuing the memory and cognition in rodent models for Alzheimers disease, protecting neurons from cell death after intracerebral hemorrhage or ischemia, recovering severe retinal degeneration and restoring the age-associated loss of the neural stem/progenitor pool

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In some embodiments, the lipid-based drug delivery formulation or composition comprises a penetration enhancer (e.g., a low molecular weight alcohol (e.g., ethanol, oleyl alcohol), alkyl methanol sulphoxides, N-methyl-2-pyrrolidone, fatty amines (e.g., oleylamine), fatty acids (e.g., oleic acid, palmitoleic acid, linoleic acid, myristate acid), gluconic acid (the hexonic acid derived from glucose by oxidation of the aldehyde group at C-1 to a carboxyl group) and its derivatives, such as gluconolactone (especially, glucono-D-lactone, a chelating agent produced by the oxidation of glucose), azone and propylene glycol, singly or in combination)