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Rani Therapeutics Announces Preclinical Data Demonstrating Successful Oral Delivery of Semaglutide via RaniPill HC - Oral semaglutide administered via the RaniPill HC (RT-116) demonstrated comparable bioavailability, pharmacokinetics and weight loss to subcutaneous administration - - RT-116 was well tolerated with no serious adverse events - - Data adds to growing body of evidence of the RaniPill platforms potential to enable oral delivery of multiple obesity treatments - - Phase 1 study for RT-114, an oral GLP-1/GLP-2 dual agonist for the treatment of obesity, expected to initiate in 2025 - SAN JOSE, Calif., Feb

Most notably, the FDA approved Wegovy to reduce the risk of overweight or obese patients with cardiovascular disease

Founder pups were genotyped as described below and backcrossed to C57BL/6J mice for at least four generations before experimentation

Supply chain management The supply chain of this tablet involves multiple links such as raw material procurement, production and processing, quality inspection, and logistics distribution

SLU-PP-332 is a small-molecule studied for its relevance to ERR alpha, ERR beta, and ERR gamma pathway research, mitochondrial biogenesis research models, oxidative metabolism pathways, skeletal-muscle biochemical models, fatty-acid oxidation research environments, and cellular respiration pathway models

10.1016/j.earlhumdev.2022.105588 25 BraunschweigD.Van De WaterJ