no weight loss on compounded semaglutide NYC FDA says 'no clinical need'

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The medication isn't magic

doi: 10.1001/jama.2017.14752 39 WilliamsDMRuslanAMKhanRVijayasingamDIqbalFShaikhAet al

This muscle loss is concerning because: It can impact metabolism and physical function It reduces your bodys ability to maintain blood sugar control It increases the risk of frailty as you age It creates a more challenging cycle once medications are discontinued 3

However, as of 2026 this central IRB mechanism is not universally adopted, so sponsors should plan assuming separate IRB submissions, unless your sites specifically agree to rely on a central IRB

For those who need to slim down but dont want to lose muscle in the process, this is huge