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When used directly on the skin, berberine may help to improve burns, and bacterial infections, like trachoma, fungal infections, and protozoa that affect the skin

Jett L, Lger R, Thibaudeau K, Benquet C, Robitaille M, Pellerin I, Paradis V, van Wyk P, Pham K, Bridon DP

Ingredients: Water, Niacinamide, Glutathione, Vitamin C, Ceramide, Stearic Acid, Isopropyl Myristate, Glycerin, Glycol Stearate, Mineral Oil, Petrolatum, Dimethicone, Disodium EDTA, Fragrance, Titanium Dioxide, Methylparaben, Propylparaben.

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According to a 2020 meta-analysis published in Clinical Nutrition ESPEN, berberine may help to improve metabolic parameters and reduce body weight and obesity without increasing liver enzymes ( 6 )

I have not been taking it long enough to evaluate its effectiveness