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*Correspondence: Hui Zhao [email protected] This article was submitted to Gastroenterology, a section of the journal Frontiers in Medicine ORCID: Na Li orcid.org/0000-0003-2567-3992 Hui Zhao orcid.org/0000-0001-6358-7978 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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B-2 (riboflavin): Riboflavin is another B-complex vitamin that plays a key role in converting food into energy, making it essential for a healthy metabolism

An upregulated level of pro-inflammatory cytokine IL-6 was found in the serum of HCC patients (Xu et al., 2021), and the IL-6/STAT3 signaling pathway has been frequently shown to be constitutively activated in HCC patients, which is associated with poor prognosis (Li et al., 2023a), affecting activities of anti-apoptosis, angiogenesis, proliferation, invasion, metastasis, and drug resistance of HCC cells (Xu et al., 2021)