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Barriers to translation There has yet to be a full accounting of the promise and price of GLP-1R agonists --only time will tell

Currently, yes semaglutide has proven cardiovascular benefit from the SELECT trial (2023), which demonstrated significant reduction in major adverse cardiovascular events (heart attack, stroke, cardiovascular death) in patients with obesity and established heart disease

Clinical evidence shows weight is regained gradually if the medication is discontinued without lifestyle changesthe same pattern seen with any weight-loss intervention

the glucagon arm additionally nudges energy expenditure and hepatic fat handling upward

To administer injectable GLP-1 medications, youll need to use the single-use injector pen that the products come in

Do not use if you or a family member has a history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2)