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Bacteriostatic water maintains preservative efficacy for up to 28 days after first puncture when stored at 2-8C

J Clin Epidemiol 47:1021-1026 11: Abdalla DSP, Monteiro HP, Oliveira JAC, et al (1986)

Less commonly, polymorphisms in the MC1R gene (common in individuals with red hair and Fitzpatrick type I skin) reduce receptor responsiveness to exogenous agonists, requiring higher doses or longer loading phases to achieve visible results

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