Additionally, OS has been proposed to play a role in the pathogenesis of canine hepatozoonosis and trypanosomosis and may be related to the development of anemia due to increased lipid peroxidation in erythrocytes [162,163]
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Inflammation-associated anorexia, prevalent gastrointestinal symptoms due to slow intestinal transit, disrupted appetite regulation, and energy expenditurelinked to overexpression of leptin, increased bound leptin, irregular ghrelin secretion, and blunted ghrelin responsescorrelate with liver disease severity and systemic inflammation, further reducing food intake quantity and frequency of spontaneous food consumption (12, 16)
PON-1 is primarily secreted by the liver [89]
If irritation or sensitivity develops, discontinue use of the product and consult the clinic.