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doi: 10.1074/jbc.RA119.007896 21 AryaPNSaranyaISelvamuruganN

The spin-trap agent NXY-059 has shown to reduce stroke impairment (241) and to confer protection toward tPA-induced hemorrhage (242) in animal models of stroke

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[206] evaluated the effects of SAMe on global and site-specific DNA methylation and gene expression in the context of LPS-stimulated inflammation in human macrophages, and found a decrease in DNA methylation status of inflammatory genes after SAMe treatment