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What the Data Shows The honest answer, based on the published evidence, is mixed rather than negative

As a peptide that declines with age and intersects with many well-established longevity pathways, it stands to have significant effects on age-related decline - Cardiometabolic health: Research suggests improvements in several markers associated with metabolic syndrome, but more studies are required regarding cardiovascular outcomes in humans

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This paper describes the extracellular component of TSHR as the most immunogenic form, stimulating its use as an efficient mouse immunization model of hyperthyroidism from TSHR autoantibodies

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