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Serious adverse events are rare and most often occur in patients with personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN2), which your PlexusDx provider screens for before starting therapy

Sematrinity 4mg Pre-filled Pen| Maximum Semaglutide Weight Loss Injection: Complete dosage guide, uses and side effects

2025 Sep 18;393(11):1077-1087

Not reassuring either

Even so, these serious adverse events are usually quite rare, as less than 1% of patients who received a drug in violation of a black box warning experienced serious adverse effects as a result of taking the drug

Mejlhede MAB, Jepsen JB, Knudsen UB