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Table 2 Overview of the SURPASS clinical trial program with tirzepatide in the therapy of type 2 diabetes

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hormone-based metabolic understanding

Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7-36)amide, peptide histidine methionine and is responsible for their degradation in human serum

GIP Pathway (Glucose-Dependent Insulinotropic Polypeptide) Improves insulin sensitivity and may promote more favorable fat distribution