Main Research Findings 1) Dihexa was shown to improve cognitive impairments and recover memory by inhibiting inflammation and decreasing neuronal loss by affecting the PI3K/AKT signaling pathways
Due to the Reaction Chamber technology, the established process is linearly scalable to Dyhydromatics pilot or production scale high-shear processors
Rodent behavioural paradigms (such as Morris water maze or novel object recognition) provide complementary in vivo endpoints for studying cognitive function-related signalling research questions.
It was identified through a medicinal chemistry programme at the University of Texas Health Science Center as the lead NNMT inhibitor candidate among a series of 1-methylquinolinium analogues bearing primary amine substitutions, selected for its combination of high passive membrane permeability (confirmed in PAMPA assays), high active transport membrane permeability (confirmed in bidirectional Caco-2 cell assays), potent NNMT inhibitory activity, and high selectivity including confirmed absence of inhibitory effects on related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway
Direct interaction with the androgen receptor, the estrogen receptor, the aromatase enzyme, or prolactin secretion
NOTICE: By purchasing this product, the buyer acknowledges that the product is supplied in lyophilized (freeze-dried) form and is intended strictly for laboratory research purposes
