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Ghrelin, a stomach-derived hormone that stimulates GH secretion, can be increased in individuals with PWS before the onset of obesity, which is a distinct feature not typically seen in common obesity or other genetic obesities (111, 112)

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CHAC1 is often induced under cellular stress, including unfolded protein response signaling, and its activation modulates redox balance and influences apoptosis and ferroptosis 30

Retrieved from Gautam, D., Purandare, N., Maxwell, C