Post-weight-loss patients undergoing body contouring surgery (particularly longer procedures such as a body lift (belt lipectomy) or combined abdominoplasty (tummy tuck) and thighplasty (thigh lift)) sit at the higher end of the risk spectrum for several reasons (4, 9), and B12 deficiency is one contributor
[DOI] [PubMed] [Google Scholar] Baggio L
In high-risk patients, use semaglutide with caution
Matek D, Matek I, Staresinic E, Japjec M, Bojanic I, Boban Blagaic A, et al
A prime example of these new skincare ingredient trends is the use of microscopic spicules from marine sponges, which create tiny, invisible channels to allow deeper penetration of active ingredients without tearing the surface of your face, echoing the rise of bioidentical aesthetics that stimulate natural repair instead of relying on heavy fillers
Phase 3 Update: TRIUMPH-4 Results Preliminary data from the ongoing Phase 3 TRIUMPH-4 trial (68 weeks) shows higher numbers than Phase 2: 12mg dose: 28.7% average weight loss (~71 lbs / 32 kg) 9mg dose: 26.4% average weight loss (~64 lbs / 29 kg) Knee osteoarthritis pain: 76% reduction (significant quality-of-life improvement) Blood pressure: Average reduction of 14 mmHg Full Phase 3 results across the TRIUMPH program (obesity, diabetes, cardiovascular outcomes, kidney outcomes) are expected throughout 2026
