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Alpha-synuclein induces activated astrocytes to release VEGF-A and NO, leading to vascular damage and the downregulation of TJs [228, 229]

Do not stop propranolol suddenly unless a clinician tells you to do so

J Pharmacol Exp Ther 238:5461 Atkuri KR, Mantovani JJ, Herzenberg LA, Herzenberg LA (2007) N -Acetylcysteinea safe antidote for cysteine/glutathione deficiency

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TLR signaling pathways activate NF-B (via IKK/IKK), AP-1 (via MAPKs), and IRF 3 (via TBK1, IKK, and IKK)

Furthermore, it is crucial to determine whether FXR activation or inactivation varies among different tissues