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As a glucagon-like peptide-1 (GLP-1) receptor agonist used clinically to treat type 2 diabetes mellitus, liraglutide improves endothelial dysfunction caused by hyperglycemia, thereby preventing angiogenesis disorders in C57BLKs/J mice of wound model

Ko et al found that 8 weeks of treadmill exercise beginning 2 weeks after TBI suppressed the expression of the pro-apoptotic protein Bax and increased the expression of the anti-apoptotic protein Bcl-2 in the hippocampal dentate gyrus of rats and improved spatial learning ability, indicating that treadmill exercise after TBI can inhibit neuronal apoptosis in the brain by suppressing TBI-induced activation of the CREB/BDNF/TrkB signaling pathway after TBI [132]

The NTD of GLP-1R is one of its key regions for ligand binding

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Benefits of L-Carnitine Intake: Promotes the transport and transformation of fats into energy