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According to Kelly, the following should take caution: Those with a personal or family history of thyroid cancer Elderly patients due to increased risk of fractures (a DEXA scan is completed first to determine their bone density) Those who have lost weight (medically or not) and still have their gallbladder, with three gallbladder attacks in the past year Diabetics with a history of retinopathy (Kelly will first reach out to their ophthalmologist) Final words These medications may have become synonymous with Hollywood in recent years, but there are tangible benefits and risk reduction for cardiovascular patients