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On examination, there are swollen , bluish , tender lumps around the anal verge , consistent with thrombosed external hemorrhoids

Pickart and Margolina's 2018 review catalogued over 4,000 human genes reportedly modulated by GHK-Cu exposure, including upregulation of collagen synthesis genes (COL1A1, COL4A1), matrix metalloproteinase regulators, and antioxidant enzymes [11]

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In the model control group, the granulation tissues formed were hypocellular and covered by a thin immature epithelium

Insert needle at 45-90 degree angle