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BPC-157 was isolated from gastric juice, and Sikiric's group demonstrated in animal studies that orally administered BPC-157 produces measurable effects on GI tissue and, in some models, systemic tissue

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[DOI] [PMC free article] [PubMed] [Google Scholar] Hamedi M, Mohammdi M, Ghaleiha A, Keshavarzi Z, Jafarnia M, Keramatfar R, Alikhani R, Ehyaii A, Akhondzadeh S (2014) Bupropion in adults with attention-deficit/hyperactivity disorder: a randomized, double-blind study

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This action is further enhanced when combined with PI3K inhibitors, making it a promising combination therapy