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However, upon exposure to a solution containing GSH, the GSH reacts with the probe through aromatic nucleophilic substitution, leading to the formation of a thiol skeleton with enhanced electron transfer and the subsequent emission of the bright optical signal

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For example, subtypes marked by pronounced metabolic or inflammatory signatures (e.g., hyperandrogenic with obesity and insulin resistance) are more likely to exhibit heightened NETassociated inflammation, whereas subtypes with milder metabolic features may derive less direct benefit from NETfocused intervention