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In an adult patient currently taking sertraline (Zoloft) for depression, is it safe to start Qsymia (phenterminetopiramate) for weight loss, considering potential cardiovascular and seizure risks?

These agents have also demonstrated additional metabolic benefits such as delayed gastric emptying and reduced appetite, which contribute to improved overall glycaemic outcomes and cardiometabolic health 7

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These effects may be mediated by PPAR, MAP K, NF-B and other signal transduction factors

Creatine supports intramuscular water retention, strength maintenance, and may provide anti-catabolic benefits during caloric restriction

Because it is a substance your body already creates, it is usually very well-tolerated