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doi: 10.3390/ijms21010284, 180 SedleyW

SS31 (elamipretide) is a mitochondriatargeted tetrapeptide that selectively binds cardiolipin in the inner mitochondrial membrane [1] , stabilizing electron transport chain complexes and reducing reactive oxygen species production while enhancing ATP synthesis [2]

Its small size confers favorable physicochemical properties for solubility, stability, and intranasal or subcutaneous delivery, but also raises questions about specificity that are common to short peptides in vivo proteolytic stability, off-target binding, and minimum receptor recognition motif identification all require additional characterization that the published literature does not yet fully provide

Adipose-derived stem cells are being utilized in combination with skin treatments to improve the appearance of the skin and with fat grafts to increase graft survival and promote dermal regeneration. 3 Exosome-based therapies are gaining popularity as well, said Joseph

December 13, 2017