First, the Phase 2 retatrutide dose ladder (1, 4, 8, 12 mg weekly per Jastreboff et al
The starting dose of 0.25 mg weekly is intentionally low to help your body adjust to the medication and minimize side effects like nausea
As of November 2025, nearly 80% (77.8%) of all Microdose GLP-1Rx users stayed engaged with the Noom app for 4 or more weeks, and D30 engagement for our December cohort was over 40% (43.6%), 1 which is at least 10 times higher than average health, medical, and fitness app retention
To be on the safe side, Gendreau says it's better to ignore the front of the box and refer to the official Nutritional Facts Panel on the back
Six therapeutic research areas
Also, studies demonstrate significant reductions in waist circumference, post-meal glucose, triglycerides, body weight, and body fat while supporting healthy insulin function