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FIGURE 3 Low bioavailability remains a major hurdle for harnessing the therapeutic benefits of PCs, necessitating innovative delivery approaches such as nano-encapsulation, phospholipid complexation, and co-administration with permeability enhancers

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So EGF is a plausible cell-renewal signal with a real mechanism, not a guaranteed pigment shield, and a randomized controlled trial of microneedling combined with topical growth factors did report improvements in skin parameters with no adverse effects, which supports the pairing of needling and growth-factor delivery while stopping well short of overpromising