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Some of the health issues linked to the use of GLP-1 drugs and dual GIP/GLP-1 medications include pancreatitis, gallbladder problems, kidney disease, heart palpitations, and gastrointestinal health problems

Bisacodyl (Dulcolax), sodium picosulfate, and senna are common stimulant laxatives

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For larger fat deposits, abdomen, flanks or post-GLP-1 patients Aqualyx remains the more predictable clinical choice

The combination of large extracellular domains (ECD), extended orthosteric binding sites, and conformational flexibility makes class B1 GPCRs interesting but challenging targets for rational ligand discovery and particularly demanding benchmarks for computational ligand design and virtual screening methodologies (Aksu et al., 2024

10.3390/ijms25031818 204 YoonC