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Readers should discuss medical history, allergies, current medications, pregnancy or breastfeeding, wound status, and regulatory status with a qualified clinician before making peptide-related medical decisions

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UPR activation varies across different brain regions and disease contexts, reflecting the selective vulnerability of neuronal populations

However, the reduction in glucotoxicity with SGLT2-I and improved insulin sensitivity may result in increased benefit in patients with more elevated baseline A1c

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